Hereditary angioedema (HAE) is a hereditary disorder that causes severe swelling, usually in the limbs, face, airway, and intestines. This can lead to abdominal pain, nausea, vomiting, and life-threatening airway obstruction. Swelling can be triggered by stress but often has no clear cause.

A rash called erythema marginatum occurs during attacks in about a third of patients. Episodes involving the intestinal tract cause severe abdominal pain, nausea, and vomiting. Swelling in the airway can restrict breathing and lead to life-threatening obstruction of the airway

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